For the Love of Enzymes读书介绍
| 类别 | 页数 | 译者 | 网友评分 | 年代 | 出版社 |
|---|---|---|---|---|---|
| 书籍 | 352页 | 2020 | Harvard University Press |
| 定价 | 出版日期 | 最近访问 | 访问指数 |
|---|---|---|---|
| USD 29.95 | 2020-02-20 … | 2021-02-10 … | 14 |
In 1645 the Japanese samurai Musashi Miamoto wrote "A Book of Five Rings," which described the attitudes necessary for individual success. Though he was a swordsman, his book was not limited to combat but addressed the much broader question of how to achieve excellence in life through study, discipline, and planning. It is still avidly read in Japan today. Arthur Kornberg's book is a modern-day "Book of Five Rings" that replaces the medium of swordsmanship with that of biochemistry, particularly enzymology. As Kornberg describes his successive research problems, the challenges they presented, and the ultimate accomplishments that resulted, he provides us with a primer in the strategies needed to do scientific work of great significance. Moreover, these strategies are played out in the context of solving some of the great biochemical problems of the twentieth century. The ability to manipulate and alter DNA fired a revolution that forever changed the nature of biology. Arthur Kornberg is a primary architect of that revolution, arguably one of the two or three most important biologists of this time. Prior to Kornberg, genetic information and later DNA were imbued by biologists with an almost vitalistic aura. Kornberg demonstrated that DNA is a molecule synthesized by enzymes, like all other chemical constituents of the cell. More important, he trained a school of scientists who focused on and discovered many of the enzymatic activities that act on DNA. It is these enzymes in particular that allow modern "genetic engineering." "For the Love of Enzymes" does not describe a single lucky or hard-won accomplishment. Rather, it is the story of thirty years of decisive campaigns, nearly all of which led to insights of major significance. In relating his story, Kornberg never avoids the difficult question of "why": why he felt classical nutritional studies had reached a plateau, why he turned to enzymology as a discipline in which the important answers would be found, and why he believes the study of enzymes will grow ever more important as we face the new scientific frontier of brain function. This book will challenge students of biology and chemistry at all levels who want to do important work rather than simply follow popular trends. It will also delight and inform readers who wish to understand how "real" science is done, and to learn of the values that guide one of our greatest researchers.
作者简介阿瑟·科恩伯格（Arthur Kornberg），美国生物化学家，1918年3月12日生于纽约。1941年他获得博士学位，1953年任华盛顿大学教授。科恩伯格主要的成就是酶化学。他成功地从大肠杆菌提取液中分离出DNA聚合酶，为此，1959年，科恩伯格与他的老师、西班牙裔美国生物化学家奥乔亚(1905～1993) 共同获得了诺贝尔生理学及医学奖。
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